CLSI H 21-A5 PDF

CLSI HA5 Collection, Transport, and Processing of Blood Specimens for Testing Plasma-Based Coagulation Assays and Molecular Hemostasis Assays;. CLSI HA5. Collection, Transport, and Processing of Blood Specimens for Testing Plasma-Based Coagulation Assays; Approved Guideline. HA5 does not provide general guidelines for the performance of coagulation testing. Performance guidelines for specific coagulation assays are addressed.

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Best Practice Collection Technique S1. A clear statement describing the magnitude and direction of the interference must be included. Published clinical outcome studies describing performance requirements for the specific analyte. Factors Affecting Haemolysis, specimencare.

Similarly, brown coloured serum due to methaemalbumin, normal results for potassium or the same result from arterial and venous collections should prompt further investigation e.

Quantitative Estimation of Haemolysis S2. This standard is not included in any packages. Non standardisation of units. We have no amendments or corrections for this standard. Haemolysis as influence and interference factor. Requests to do so should be addressed to the Editor. Ann Acad Med Singapore. Areas to consider could include data mining, guidance on how to perform in-house studies and the defining of appropriate action limits.

Your Alert Profile lists the documents 21a-5 will be monitored. The interference with immunoassays is less frequent than with photometric assays, but is still a significant consideration; one of the most commonly affected immunoassays are the cardiac Troponin assays. Influence of hemolysis on routine clinical chemistry testing. Where semi-quantitative estimates are in use, their equivalence to a conventional unit e.

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No literary matter in The Clinical Biochemist — Reviews is to be reproduced, stored in a retrieval system or transmitted in any form by electronic or mechanical means, photocopying or recording, without permission. Clinically relevant limits can be 2-a5 from:. Clinically relevant clsii can be sourced from: When a POCT result shows a result e.

Example of a Haemolysis Colour Chart which also shows haemolysis index concentration levels across different analytical platforms Courtesy Goce Dimeski, Pathology Queensland. Observational study to determine factors associated with blood sample haemolysis in the emergency department. Please first log in with a verified email before subscribing cldi alerts. Best Practices in Phlebotomy. The interference can be the result of various mechanisms including:. If a laboratory decides to report affected tests, the H-Index levels used for these purposes must be documented.

Clin Chem Lab Med. Introduction Haemolysis of blood samples has been documented as the most frequent pre-analytical artefact encountered by laboratories. Laboratories cllsi monitor the frequency of haemolysed blood samples and investigate the source of collection to enable continuous improvement.

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Consensus Statement for the Management and Reporting of Haemolysed Specimens

Subscription pricing is determined by: The effect of hemolysis on current troponin assays confounding preanalytical variable? You may delete a document from your Alert Profile at any time.

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Journal List Clin Biochem Rev v. Whole Blood Analyses S5. Impact of Haemolysis on Test Results S3.

Laboratories must determine and document at which H-Index level recollection of the sample is appropriate. However, these guidelines may also be considered for other sample types e.

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Consensus Statement for the Management and Reporting of Haemolysed Specimens

Spectral haemoglobin absorbs at clsj, and nm – leading to interference with alkaline phosphatase, gamma-glutamyl transferase, total and direct bilirubin. Need more than one copy?

The most frequently encountered causes of haemolysis of blood samples include use of inappropriately small gauge needles during phlebotomy and transfer of blood from a syringe into a vacutainer tube via a needle e.

Support Center Support Center. Tests of the coagulation system are very sensitive to storage time and temperatureconcentration of anticoagulant, and surface of containers; attention to these parameters is important. Dilutional gross haemolysis releasing cell fluid and content – leading to false lowering of results e.

Standards Subscriptions from ANSI provides a money-saving, multi-user solution for accessing standards. A survey of Australian Laboratories enrolled in the RCPA Quality Assurance Programs confirmed an ongoing variation in the management and reporting of haemolysed samples.

Laboratories must have a means to identify affected patient results e.