Adenomatoid Odontogenic Tumour of the Maxilla – A Case Report with Review. 1 Reader. Dept of Oral Medicine and Radiology. SRM Dental College. Adenomatoid odontogenic tumour is a benign (hamartomatous), noninvasive lesion with slow but progressive growth. The 3 variants — follicular, extrafollicular . Adenomatoid odontogenic tumor is a hamartomous benign neoplasia of odontogenic origin. It appears mostly in young patients and females, the maxillary.

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Treatment is conservative and the prognosis is excellent. The lesion usually present as asymptomatic swelling which is slowly growing and often associated with an unerupted tooth. Clinical features generally focus on complaints regarding a missing tooth. However, AOT frequently resemble other odontogenic lesions such as dentigerous cysts or ameloblastoma.

Adenomatoid odontogenic tumor of the mandible: review of the literature and report of a rare case

Under general anesthesia the lesion was enucleated and afterwards filled with pelvic spongiosa. Adenomxtoid, he showed a 3 cm unicystic radiolucent image with a comparatively clear demarcation. Open in a separate window. To acquire additional information about AOT, all reports regarding AOT and cited in “pubmed” since onward were reviewed.

Limitation of panoramic radiography in diagnosing adenomatoid odontogenic tumors. Finally, Gao et al. Beyond adenomatoidd our case supports the above mentioned general description of AOTs.

This article describes two cases concerning odontoogenic young female patients who presented at our Department in the period comprised between December and February with an asymptomatic swelling with a slowly growing lesion: All authors disclaim any financial or non-financial interests or commercial associations that might pose or create a conflict of interest with information presented in this manuscript.

AOT had been initially described and classified as a variant of the ameloblastoma and has been recognized as a distinct lesion only since Case report A year-old man was referred by his general dental practitioner.


A year-old man was referred by his general dental practitioner. Some tumor droplets show a homogenous matrix whereas most tumor droplets reveal electron-dense plaques [ 15 ]. The epithelium is in the form of whorled masses of spindle cells as well as sheets and plexiform strands. The peripheral lesions may show some erosions of the adjacent cortical bone [ 11 ]. Br J Oral Maxillofac Surg.

Support Center Support Center. Recurrence of AOT is exceptionally rare. Regarding the various case series published in the literature [e. Separating the lesion from mandibular bone caused no problems. Positive reactions for amelogenin in limited areas in AOT are also reported as well as in ameloblasts and in the immature enamel matrix [ 20 ].

Adenomatoid Odontogenic Tumour: Review and Case Report

Displacement of neighbouring teeth due to tumor expansion is much more common than root resorptions. Treatment and prognosis Conservative surgical enucleation is the treatment modality of choice. Histologically, the tumor is solid and there is a cyst formation Fig. With respect to the age of the patient and the localization of the AOT in the lower jaw, the reported case is a rare example of this tumor entity. Immunohistochemical demonstration of bone morphogenic protein in odontogenic tumors.

Cite this article as. Moreover, eosinophilic, uncalcified, amorphous material can be found and is called “tumor droplets”. All authors were involved in revising the manuscript critically and have given final approval of the version to be published.

Pathohistological features Remarkably, all variants of AOT show identical histology.

Adenomatoid odontogenic tumor of the mandible: review of the literature and report of a rare case

National Center for Biotechnology InformationU. Odontogenic tumors in Mexico: However, a variety of terms have been used to describe this tumor. No resorption of the root apices was observed Fig. For illustration a rare case of an AOT in the mandible is presented. Unerupted permanent canine are the theeth most often involved in AOTs.


Tumro Adenomatoid odontogenic tumor AOT is a rare odontogenic tumor which is often misdiagnosed as odontogenic cyst. Immunhistochemical localization of amelogenin in human odontogenic tumors, adenomaoid a polyclonal antibody against bovine amelogenin. The postoperative course and follow-up were uneventful.

Some sections were stained with haematoxylin-eosin. However, the rare peripheral variant occurs primarily in the gingival tissue of tooth-bearing areas [ 9 ]. In Philipsen and Reichart [ 3 ] presented a review based on reports published until which showed some interesting aspects regarding epidemiological figures of odkntogenic tumor.

Italian Journal of Maxillofacial Surgery 2008 December;19(3):131-6

Radiographic features The radiographic findings of AOT frequently resemble other odontogenic lesions such as dentigerous cysts, calcifying odontogenic cysts, calcifying odontogenic tumors, globule-maxillary cysts, ameloblastomas, odontogenic keratocysts and periapical disease [ 10 ].

In addition, in one recently reported case MRI was useful to distinguish AOT from other lesions, even if it is difficult on periapical ordinal radiographies [ 10 ]. Interestingly, there are a few reports about pigmented cells in AOT. Therefore, the prognosis is excellent. Clinical study and evaluation of treatment results.

Whereas cementifying fibromas, dentinomas and compound odontomas demonstrated a positive reaction, all AOT as well as ameloblastomas and calcifying epithelial aenomatoid tumors were negative.

The AOT is over two times more located in the maxilla than in the mandible and the anterior jaw is much more affected than the posterior area. The surgical treatment of such neoplasm is generally conservative, provided that the removal of the lesion and the curettage of the residual area are meticulously performed; in tukor conditions recurrence is extremely rare. Remarkably, all variants of AOT show identical histology.