Integrated 3D-printed reactionware for chemical synthesis and analysis. / Symes, Mark D.; Kitson, Philip J.; Yan, Jun; Richmond, Craig J.; Cooper, Geoffrey J. T.;. ARTICLES PUBLISHED ONLINE: 15 APRIL | DOI: /NCHEM Integrated 3D-printed reactionware for chemical synthesis and analysis Mark D. Integrated 3D-printed reactionware for chemical synthesis and analysis. Mark D. Symes, Philip J. Kitson, Jun Yan, Craig J. Richmond, Geoffrey J. T. Cooper.

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Grey, black, light blue and pink represent protons, C, N and O, respectively. Further, the versatility of the 3D-printed reactionware has been demonstrated by studying and optimizing the residence time to synthesize a range of imines and secondary amines and to monitor the reactions in real time using in-line IR spectroscopy. Rachel Armstrong 4 Estimated H-index: All this is important in chemistry, and in particular for the realization of micro- and millifluidic devices.

We are currently investigating the effect of the device architecture on the reaction performed by using 3D-printed reactors made of PP, testing their robustness and chemical inertia in different environments, and designing new geometries to further develop the reactiknware printing technology and the 3D-printed reactionware, as well as the development of a range of universal chemical modules.

One holding chamber held the 4-methoxyaniline and tures.

Makoto Nakamura 12 Estimated H-index: The possibility of connecting the reactors using standard fittings allows for better seals and facilitates the reuse of the devices, compared to our previously published procedures [5].

Theory and Practice; Oxford University Press: The significant advantage of this technique is that the architecture can be concisely controlled. Technoetic Arts 7, techniques. Nuzzo Advanced functional materials Protons are omitted reavtionware clarity. Furthermore, solely by modifying reactionware architecture, reaction outcomes can be altered.

The device was then printed of the reaction chamber resealed spontaneously, making the using a robust, quick-curing acetoxysilicone polymer Loctite chamber watertight.

Direct ink writing of 3D functional materials. The thermoplastic employed to fabricate the devices presented herein is PP, selected to print robust, inexpensive and chemically inert devices. Therefore it represents a very attractive way to chenical and build new continuous-flow rigs for organic synthesis.


Integrated 3D-printed reactionware for chemical synthesis and analysis.

Architecture as Topic Search for additional papers on this topic. Biomacromolecules 11, — Ultrasonic cleaning of 3D printed objects and Cleaning Challenge Devices. Goodridge and Steven D. Imine formation Device 2: The 3D-printed devices were integrated in the flow systems using 1.

Return to citation in text: Jump to Figure 8. Integrated 3D-printed reactionware for chemical synthesis and analysis. Hence, we were able to perform bulk electrolysis on the sample the c ITO working electrode was poised at —0. Registration is open for this Beilstein Symposium, 9 – 11 April, Evan Malone 11 Estimated H-index: Active elements such as catalysts can be incorporated into the walls of printed reactors, and other printed-in components that enable electrochemical and spectroscopic analysis can also be included.

The input light source was provided by a W broad-spectrum Hg arc lamp, which was clamped below the apparatus such that the sample was irradiated from below, through the ITO window, during acqui- sition of the spectra.

Herein, we demonstrate the versatility and convenience of using 3D-printed reactors for anqlysis synthesis of organic compounds, using flow techniques with an in-line ATR-IR flow cell to monitor the reactions in real time. Dr Mark Symes is a Lord Kelvin Adam Smith Research Fellow at the University of Glasgow, with research interests in small molecule activation, energy storage and conversion, and 3D-printed reactionware for chemical synthesis.

3D-printed devices for continuous-flow organic chemistry

This is convenient from a processing point chemicwl view, since high concentrations favor increased reaction kinetics [26] whilst minimizing the amount of waste generated during the downstream work-up [27]. The use of in-line spectroscopy allows for the monitoring of reaction steps that include unstable compounds or hazardous species [18]. Jump to Figure 2. Both have two inputs A and B and one output C. Nevertheless, it is not suitable for carrying out organic reactions as it can absorb the reactants and will swell in most nonaqueous solvents [8].


The syntheses of the imines were monitored by an in-line ATR-IR flow cell and were conducted at a total flow rate of 0.

Integrated 3D-printed reactionware for chemical synthesis and analysis. – Semantic Scholar

From multiuse electrochemical cells to sensors. The choice of a short residence time is to allow for a more reliable comparison of cheical imines synthesized and also to avoid the formation of the Michael addition adduct [28] the thermodynamic compound in the reaction between compounds 1b and 2a.

Tangible visualization of molecular dynamics simulations using 3-D printing. Evaluation of 3D printing and its potential impact on biotechnology and the chemical sciences. Although the chemistry chosen to exemplify this tech- — Supplementary information and of seeded hydrogels in arbitrary geometries.

Integrated 3D-printed reactionware for chemical synthesis and analysis

Biomatrices and biomaterials for future developments of bioprinting and biofabrication. Rosnes University of Glasgow. The glass slide was employed solely to aid visu- Charge mC alization of the ensuing electrochemical reactions, and various func- tional architectures for electrochemical cells can be envisioned using —80 solely printed components.

Self-division the assembly of the reactionware, crystallization of compound 1 Supplementary of macroscopic droplets: The screw connectors increase the chemical tolerance of the 3D-printed reactor as well as its chemical compatibility, compared to our previous devices [5]. Such studies show that robocast 3D-printed reactionware is suitable for both spectroscopic analyses and bulk synthetic and electrosynthetic processes.

How to cite this article: Innovation and Technical Ptinted in Living Technology: